肿瘤免疫与微生物组研究组

研究组研究方向

1.肿瘤免疫方向：探究免疫细胞中的表观转录调控机制。

2.微生物组方向：探索微生物组在肿瘤免疫治疗中的关键作用。

研究组研究内容及意义

利用临床组织样品、肿瘤动物模型等，从“免疫细胞”和”微生物组“两个角度，浅析微生物组如何影响表观调控介导的抗肿瘤免疫反应、探究微生物组与免疫细胞的互作机制。基于研究发现的潜在靶点，开发新型有效的肿瘤免疫治疗“增敏剂”。

代表性论文（#共同第一作者，*通讯作者）

1. Wang L, Lynch C, Pitroda SP, Piffkó A, Yang K, Huser AK, et al. Radiotherapy and immunology.J Exp Med. 2024;221(7):e20232101.

2. Bugno J#,Wang L#, Yu X, Cao X, Wang J, Huang X, et al. Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance.Clin Cancer Res. 2024;CCR-23-3616.

3. Wang L#*, Si W#, Yu X#, Piffko A, Dou X, Ding X, et al. Epitranscriptional regulation of TGF-β pseudoreceptor BAMBI by m⁶A/YTHDF2 drives extrinsic radioresistance.J Clin Invest. 2023;133(24):e172919.

4. Wang L#*, Katipally RR, Liang HL, Yang K, Pitroda SP, He C, Weichselbaum RR*. RNA m⁶A methylation and MDSCs: Roles and therapeutic implications for radiotherapy.Med. 2023;4(12):863-874.

5. Wang L#, Dou X#, Chen S#, et al, Luo C*, Liang HL*, He C*, Weichselbaum RR*. YTHDF2 inhibition potentiates radiotherapy antitumor efficacy.Cancer Cell. 2023;41(7):1294-1308.e8.

6. Si W, Liang H, Bugno J, et al, Weichselbaum RR, Zhao X,Wang L*.Lactobacillus rhamnosusGG induces cGAS/STING- dependent type I interferon and improves response to immune checkpoint blockade.Gut. 2022;71(3):521-533.

7. He L#,Wang L#, Wang Z#, et al, Dimitrov DS, Du J*, Liao X*. Immune Modulating Antibody-Drug Conjugate (IM-ADC) for Cancer Immunotherapy.J Med Chem. 2021;64(21):15716-15726.

8. Ding XC#,Wang LL#, Zhang XD, et al, Weichselbaum RR*, Yu JM*, Hu M*. The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia.J Hematol Oncol. 2021;14(1):92.

9. Wang L#, Gao Y#, Zhang G#, Li D#, et al, Hu X*, Wei Z*, Wang W*, Liao X*. Enhancing KDM5A and TLR activity improves the response to immune checkpoint blockade.Sci Transl Med. 2020;12(560):eaax2282.

10. Wang L#, Si W#, Xue H, Zhao X*. Characterization of a functional insertion sequence ISSau2fromStaphylococcus aureus.Mobile DNA. 2018;16;9:3.

11. Wang L, Si W, Xue H, Zhao X*. A fibronectin-binding protein (FbpA) ofWeissella cibariainhibits colonization and infection ofStaphylococcus aureusin mammary glands.Cellular Microbiology. 2017;19(8).

12. Wang L, Xue H, Li L, Zhao X*. Characterization of insertion sequence ISSau2in the human and livestock-associatedStaphylococcus aureus.PLoS One. 2015;15;10(5):e0127183.

益生菌-LGG增强抗肿瘤免疫反应的分子机制(Gut, 2022)