代表性图片

图1 微黄白链霉菌种群系统学与Structure分析

图2 链霉菌和小单孢菌的菌落及电镜形态

图3 红壤放线菌的部分活性代谢产物

图4 Azolemycin生物合成途径解析

图5 模拟微重力及空间飞行促进链霉菌发育分化

代表性论文（^#共同第一作者; ^*通讯作者）：

1.     Wang J, Li Y, Pinto-Tomás AA, Cheng K, Huang Y^*. 2022. Habitat adaptation drives speciation of a Streptomyces species with distinct habitats and disparate geographic origins. mBio. https://doi.org/10.1128/mBio.02781-21

2.     Li Y, Huang Y^*. 2022. Distribution and evolutionary history of sialic acid catabolism in the phylumActinobacteria. Microbiol Spectr. https://doi.org/10.1128/Spectrum.02380-21

3.     Yan B, Liu N, Liu M, Du X, Shang F, Huang Y^*. 2021. Soil actinobacteria tend to have neutral interactions with other co-occurring microorganisms, especially under oligotrophic conditions. Environ Microbiol, 23(8): 4126–4140. https://doi.org/10.1111/1462-2920.15483

4.     Zhang L, Chen Y, Xia Q, Kemner KM, Shen Y, O'Loughlin EJ, Pan Z, Wang Q, Huang Y, Dong H^*, Boyanov MI^*. 2021. Combined effects of Fe(III)-bearing clay minerals and organic ligands on U(VI) bioreduction and U(IV) speciation. Environ Sci Technol, 55(9):5929-5938. https://doi.org/10.1021/acs.est.0c08645

5.     Yan B, Guo X, Liu M, Huang Y^*. 2020. Ktedonosporobacter rubrisoli gen. nov., sp. nov., a novel representative of the class Ktedonobacteria, isolated from red soil, and proposal of Ktedonosporobacteraceae fam. nov. Int J Syst Evol Microbiol, 70:1015-1025. https://doi.org/10.1099/ijsem.0.003864

6.     Zhang L, Zeng Q, Liu X, Chen P, Guo X, Ma LZ, Dong H^*, Huang Y^*. 2019. Iron reduction by diverse actinobacteria under oxic and pH-neutral conditions and the formation of secondary minerals. Chem Geol, 525: 390-399. https://doi.org/10.1016/j.chemgeo.2019.07.038

7.     Li Y, Pinto-Tomás AA, Rong X, Cheng K, Liu M, Huang Y^*. 2019. Population genomics insights into adaptive evolution and ecological differentiation in streptomycetes. Appl Environ Microbiol, 85: e02555-18. https://doi.org/10.1128/AEM.02555-18

8.     Song F, Liu N, Liu M, Chen Y, Huang Y^*. 2018. Identification and characterization of mycemycin biosynthetic gene clusters in Streptomyces olivaceus FXJ8.012 and Streptomyces sp. FXJ1.235. Mar Drugs, 16: 98.

9.     Zhang L, Dong H^*, Liu Y, Bian L, Wang X, Zhou Z, Huang Y^*. 2018. Bioleaching of rare earth elements from bastnaesite-bearing rock by actinobacteria. Chem Geol, 483: 544-557. https://doi.org/10.1016/j.chemgeo.2018.03.023

10.   Zhang L, Xi L, Ruan J, Huang Y^*. 2017. Kocuria oceani sp. nov, isolated from a deep-sea hydrothermal plume. Int J Syst Evol Microbiol, 67: 164-169.

11.   Chen P, Zhang L, Guo X, Dai X, Liu L, Xi L, Wang J, Song L, Wang Y, Zhu Y, Huang L, Huang Y^*. 2016. Diversity, biogeography, and biodegradation potential of actinobacteria in the deep-sea sediments along the Southwest Indian Ridge. Front Microbiol, 7: 1340. https://doi.org/10.3389/fmicb.2016.01340

12.   Cheng K, Rong X^*, Huang Y^*. 2016. Widespread interspecies homologous recombination reveals reticulate evolution within the genus Streptomyces. Mol Phylogenet Evol, 102: 246-254. http://dx.doi.org/10.1016/j.ympev.2016.06.004

13.   Liu N^#, Song L^#, Liu M^#, Shang F, Anderson Z, Fox DJ, Challis GL^*, Huang Y^*. 2016. Unique post-translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264. Chem Sci, 7(1): 482-488. https://doi.org/10.1039/c5sc03021h

14.   Liu M^#, Liu N^#, Shang F, Huang Y^*. 2016. Activation and identification of NC-1, a cryptic cyclodepsipeptide from red soil-derivedStreptomycessp. FXJ1.172. Eur J Org Chem, 23: 3943-3948. https://doi.org/10.1002/ejoc.201600297.

15.   Liu N^#, Song F^#, Shang F, Huang Y^*. 2015. Mycemycins A-E, new dibenzoxazepinones isolated from two different streptomycetes. Mar Drugs, 13(10): 6247-6258. https://doi.org/10.3390/md13106247

16.   Huang B, Liu N, Rong X, Ruan J, Huang Y^*. 2015. Effects of simulated microgravity and spaceflight on morphological differentiation and secondary metabolism of Streptomyces coelicolor A3(2). Appl Microbiol Biotechnol, 99(10): 4409-4422. https://doi.org/10.1007/s00253-015-6386-7

17.   Guo X^#, Liu N^#, Li X, Ding Y, Shang F, Gao Y, Ruan J, Huang Y^*. 2015. Red soils harbour diverse culturable actinomycetes that are promising sources of novel secondary metabolites. Appl Environ Microbiol, 81: 3086-3103. https://doi.org/10.1128/AEM.03859-14

18.   Cheng K^#, Rong X^#, Pinto-Tomás A, Fernández-Villalobos M, Murillo-Cruz C, Huang Y^*. 2015. Population genetic analysis of Streptomyces albidoflavus reveals habitat barriers to homologous recombination in the diversification of streptomycetes. Appl Environ Microbiol, 81: 966-975. https://doi.org/10.1128/AEM.02925-14

19.   Rong X, Doroghazi JR, Cheng K, Zhang L. Buckley DH, Huang Y^*. 2013. Classification of Streptomyces phylogroup pratensis (Doroghazi and Buckley, 2010) based on genetic and phenotypic evidence, and proposal of Streptomyces pratensis sp. nov. Syst Appl Microbiol, 36: 401-407.

20.   Liu N, Shang F, Xi L, Huang Y^*. 2013. Tetroazolemycins A and B, two new oxazole-thiazole siderophores from deep-sea Streptomyces olivaceus FXJ8.012. Mar Drugs, 11: 1524-1533.

21.   Rong X, Huang Y^*. 2012. Taxonomic evaluation of the Streptomyces hygroscopicus clade using multilocus sequence analysis and DNA-DNA hybridization, validating the MLSA scheme for systematics of the whole genus. Syst Appl Microbiol, 35:7-18.

22.   Wang H^#, Liu N^#, Xi L, Rong X. Ruan J, Huang Y^*. 2011. Genetic screening strategy for rapid access to polyether ionophore producers and products in actinomycetes. Appl Environ Microbiol, 77: 3433-3442.

23.   Rong X, Liu N, Ruan J, Huang Y^*. 2010. Multilocus sequence analysis of Streptomyces griseus isolates delineating intraspecific diversity in terms of both taxonomy and biosynthetic potential. Antonie van Leeuwenhoek, 98: 237-248.

24.   Rong X, Huang Y^*. 2010. Taxonomic evaluation of the Streptomyces griseus clade using multilocus sequence analysis and DNA-DNA hybridization, with proposal to combine 29 species and three subspecies as 11 genomic species. Int J Syst Evol Microbiol, 60: 696-703.

25.   Gao P, Huang Y^*. 2009. Detection, distribution, and organohalogen compound discovery implications of the reduced flavin adenine dinucleotide-dependent halogenase gene in major filamentous actinomycete taxonomic groups. Appl Environ Microbiol, 75: 4813-4820. 

26.   Rong X, Guo Y, Huang Y.^* 2009. Proposal to reclassify the Streptomyces albidoflavus clade on the basis of multilocus sequence analysis and DNA-DNA hybridization, and taxonomic elucidation of Streptomyces griseus subsp. solvifaciens. Syst Appl Microbiol, 32: 314-322.

27.   Qiu D, Ruan J, Huang Y.^* 2008. Selective isolation and rapid identification of members of the genus Micromonospora. Appl Environ Microbiol, 74: 5593-5597.

28.   Guo Y, Zheng W, Rong X, Huang Y.^* 2008. A multilocus phylogeny of Streptomyces griseus 16S rRNA gene clade: use of multilocus sequence analysis for streptomycete systematics. Int J Syst Evol Microbiol, 58: 149-159.  

黄英, 张利敏, 郗丽君, 宋磊. 一株深海放线菌及其应用. 授权号：XL201410534724.4, 授权日期: 2017.06.09 

黄英, 刘宁, 郗丽君, 张利敏. 一株海洋链霉菌及其应用. 授权号：ZL201110140088.3, 授权日期: 2012.12.19 

黄英, 刘宁, 郗丽君, 张利敏. 海洋链霉菌产生的化合物及其应用. 授权号：ZL201110174314X, 授权日期: 2013.03.20