代表性成果

  1. Bo Liu, Shuman Xiang, Guang Zhao, Bojun Wang, Yanhe Ma *, Weifeng Liu *, Yong Tao. 2019. Efficient production of 3-hydroxypropionate from fatty acids feedstock in Escherichia coli. Metabolic Engineering. Jan; 51:121-130.

  2. Cheng Zhou, Hongliang Qin, Xiujuan Chen, Yan Zhang, Yanfen Xue, Yanhe Ma *. 2018. A novel alkaline protease from alkaliphilic Idiomarina sp. C9-1 with potential application for eco-friendly enzymatic dehairing in the leather industry. Scientific Reports. Nov 7;8(1):16467.

  3. Cheng Zhou, Yanfen Xue, Yanhe Ma*. 2018. Characterization and high-efficiency secreted expression in Bacillus subtilis of a thermo-alkaline β-mannanase from an alkaliphilic Bacillus clausii strain S10. Microbial Cell Factories. Aug 11;17(1):124.

  4. Cheng Zhou, Yanfen Xue, Yanhe Ma*. 2017. Cloning, evaluation, and high-level expression of a thermo-alkaline pectate lyase from alkaliphilic Bacillus clausii with potential in ramie degumming. Applied Microbiology and Biotechnology. 101:3663–3676.

  5. Cheng Zhou, Yanfen Xue, Yanhe Ma*. 2017. Characterization and overproduction of a thermo-alkaline pectatelyase from alkaliphilic Bacillus licheniformis with potential in ramie degumming. Process Biochemistry. 49-58.

  6. Caili Zhang#, Cheng Zhou#, Nilnate Assavasirijinda, Bo Yu, Limin Wang* and Yanhe Ma. 2017. Non-sterilized fermentation of high optically pure d-lactic acid by a genetically modified thermophilic Bacillus coagulans strain. Microbial Cell Factories. 16:213.

  7. Meixia Liu, Chun-Chi Chen, Lu Chen, Xiansha Xiao, Yingying Zheng, Jian-Wen Huang, Weidong Liu, Tzu-Ping Ko, Ya-Shan Cheng, Xinxin Feng, Eric Oldfield, Rey-Ting Guo*, Yanhe Ma*. 2016. Structure and Function of a “Head-to-Middle” Prenyltransferase: Lavandulyl Diphosphate Synthase. Angewandte Chemie-International Edition. pr 4;55(15):4721-4.

  8. Deyong Ge, Yanfen Xue, Yanhe Ma*. 2016. Two unexpected promiscuous activities of the iron–sulfur protein IspH in production of isoprene and isoamylene. Microbial Cell Factories. 15:79.

  9. Nilnate Assavasirijinda, Deyong Ge, Bo Yu, Yanfen Xue, Yanhe Ma*. 2016. Efficient fermentative production of polymer-grade d-lactate by an engineered alkaliphilic Bacillus sp. strain under non-sterile conditions. Microbial Cell Factories. 15:3.

  10. Yajian Song, Jinshan Li, Shan Meng, Liang Yin, Yanfen Xue, Yanhe Ma*. 2016. A Novel Manno-Oligosaccharide Binding Protein Identified in Alkaliphilic Bacillus sp. N16-5 Is Involved in Mannan Utilization. PLoS One. 11(3):e0150059.

  11. Kai Jiang, Yanfen Xue, Yanhe Ma*. 2015. Identification of N(α)-acetyl-α-lysine as a probable thermolyte and its accumulation mechanism in Salinicoccus halodurans H3B36. Scientific Reports. 5: 18518.

  12. Kai Jiang, Yanfen Xue, Yanhe Ma*. 2015. Complete genome sequence of Salinicoccus halodurans H3B36, isolated from the Qaidam Basin in China. Standards in Genomic Sciences. 10:116.

  13. Cheng Zhou, Jintong Ye, Yanfen Xue, Yanhe Ma*. 2015. Directed Evolution and Structural Analysis of Alkaline Pectate Lyase from the Alkaliphilic Bacterium Bacillus sp. Strain N16-5 To Improve Its Thermostability for Efficient Ramie Degumming. Applied and Environmental Microbiology. 81(17): 5714-5723.

  14. Cheng Zhou, Yanfen Xue, Yanhe Ma*. 2015. Evaluation and directed evolution for thermostability improvement of a GH 13 thermostable α-glucosidase from Thermus thermophilus TC11. BMC Biotechnology. 15:97.

  15. Liang Yin, Yanfen Xue, Yanhe Ma*. 2015. Global Microarray Analysis of Alkaliphilic Halotolerant Bacterium Bacillus sp. N16-5 Salt Stress Adaptation. PLoS One. 10(6): e0128649.

  16. Lei Zhai, Yanfen Xue, Yuehao Song, Mingjie Xian, Liang Yin, Naiqin Zhong, Guixian Xia, Yanhe Ma*. 2014. Overexpression of AaPal, a peptidoglycan-associated lipoprotein from Alkalomonas amylolytica, improves salt and alkaline tolerance of Escherichia coli and Arabidopsis thaliana. Biotechnology Letters. 36(3): 601-607.

  17. Yajian Song, Yanfen Xue, Yanhe Ma*. 2013. Global Microarray Analysis of Carbohydrate Use in Alkaliphilic Hemicellulolytic Bacterium Bacillus sp. N16-5. PLoS One. 8(1): e54090.

  18. Lang Rao, Yanfen Xue, Yingying Zheng, Jian R. Lu*, Yanhe Ma*. 2013. A Novel Alkaliphilic Bacillus Esterase Belongs to the 13th Bacterial Lipolytic Enzyme Family. PLoS One. 8(4): e60645.

  19. Wenqin Bai, Yanfen Xue, Cheng Zhou, Yanhe Ma*. 2012. Cloning, expression and characterization of a novel salt tolerant xylanase from Bacillus sp. SN5. Biotechnology Letters. 34: 2093–2099.

  20. Ying Meng, Yanfen Xue, Bo Yu, Chenghua Gao, Yanhe Ma*. 2012. Efficient production of L-lactic acid with high optical purity by alkaliphilic Bacillus sp. WL-S20. Bioresource Technology. 116: 334–339.

  21. Guimin Zhang, Shunyi Li, Yanfen Xue, Liangwei Mao, Yanhe Ma*. 2012. Effects of salts on activity of halophilic cellulose with glucomannanase activity isolated from alkaliphilic and halophilic Bacillus sp. BG-CS10. Extremophiles. 16: 35-43.

  22. Jinshan Li#, Wei Wang#, Yanhe Ma, Anping Zeng*. 2012. Medium optimization and proteome analysis of (R,R)-2,3-butanediol production by Paenibacillus polymyxa ATCC 12321. Applied Microbiology and Biotechnology. 97(2): 585-597.

  23. Lang Rao, Yanfen Xue, Cheng Zhou, Jin Tao, Gang Li, Jian R. Lu*, Yanhe Ma*. 2011. A thermostable esterase from Thermoanaerobacter tengcongensis opening up a new family of bacterial lipolytic enzymes. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 2011 Dec;1814(12):1695-702

  24. Chenghua Gao, Yanfen Xue, Yanhe Ma*. 2011. Protoplast transformation of recalcitrant alkaliphilic Bacillus sp. with methylated plasmid DNA and a developed hard agar regeneration medium. PLoS One. 2011;6(11):e28148.

  25. Chaoning Liang, Marco Fioroni, Francisco Rodriguez-Ropero, Yanfen Xue, Ulrich Schwaneberg*, Yanhe Ma*. 2011. Directed evolution of a thermophilic endoglucanase (Cel5A) into highly active Cel5A variants with an expanded temperature profile. Journal of Biotechnology. 2011 Jun 10;154(1):46-53.

  26. Taicheng Zhu, Lijin You, Fuyu Gong, Minfeng Xie, Yanfen Xue, Yin Li*, Yanhe Ma*. 2011. Combinatorial strategy of sorbitol feeding and low-temperature induction leads to high-level production of alkaline β-mannanase in Pichia pastoris. Enzyme and Microbial Technology. Sep 10;49(4):407-12

  27. Xiaowei Wang, Yanfen Xue, Yanhe Ma*. 2011. Streptohalobacillus salinus gen. nov., sp. nov., a moderately halophilic, Gram-positive, facultative anaerobe isolated from subsurface saline soil. International Journal of Systematic and Evolutionary Microbiology. May;61(Pt 5):1127-32.

  28. Yueju Zhao, Yunhua Zhang, Yang Cao, Jianxun Qi, Liangwei Mao, Yanfen Xue, Feng Gao, Hao Peng, Xiaowei Wang, George F. Gao, Yanhe Ma*. 2011. Structural analysis of alkaline β-mannanase from alkaliphilic Bacillus sp. N16-5: implications for adaptation to alkaline conditions. PLoS One. Jan 28;6(1):e14608.

  29. Chaoning Liang, Yanfen Xue, Marco Fioroni, Francisco Rodriguez-Ropero, Cheng Zhou, Ulrich Schwaneberg, Yanhe Ma*. 2011. Cloning and characterization of a thermostable and halo-tolerant endoglucanase from Thermoanaerobacter tengcongensis MB4. Applied Microbiology and Biotechnology. Jan;89(2):315-26.

  30. Gang Li, Yajian Song, Yanfen Xue, Lang Rao, Cheng Zhou, Quanhui Wang, Yanhe Ma*. 2011. Comparative proteome analysis of alkaliphilic Bacillus sp. N16-5 grown on different carbon sources. Science China Life Sciences. Jan;54(1):90-100

  31. Yanhe Ma, Erwin A. Galinski, William D. Grant, Aharon Oren*, Antonio Ventosa. 2010. Halophiles 2010: Life in Saline Environments. Applied and Environmental Microbiology. Nov; 76(21): 6971–6981.

  32. Gang Li, Lang Rao, Yanfen Xue, Cheng Zhou, Yueling Zhang, Yanhe Ma*. 2010. Cloning, expression, and characterization of a highly active alkaline pectate lyase from alkaliphilic Bacillus sp. N16-5. Journal of Microbiology and Biotechnology. Apr;20(4):670-7

  33. Cheng Zhou, Yanfen Xue, Yanhe Ma*. 2010. Enhancing the thermostability of alpha-glucosidase from Thermoanaerobacter tengcongensis MB4 by single proline substitution. Journal of Bioscience and Bioengineering. Jul;110(1):12-7

  34. Guimin Zhang, Liangwei Mao, Yueju Zhao, Yanfen Xue, Yanhe Ma*. 2010. Characterization of a thermostable xylanase from an alkaliphilic Bacillus sp. Biotechnology Letters. Dec;32(12):1915-20.

  35. Yingying Zheng, Yanfen Xue, Yueling Zhang, Cheng Zhou, Ulrich Schwaneberg, Yanhe Ma*. 2010. Cloning, expression, and characterization of a thermostable glucoamylase from Thermoanaerobacter tengcongensis MB4. Applied Microbiology and Biotechnology. Jun;87(1):225-33.

  36. Cheng Zhou, Yanfen Xue, Yueling Zhang, Yan Zeng, Yanhe Ma*. 2009. Recombinant expression and characterization of Thermoanaerobacter tengcongensis thermostable alpha-glucosidase with regioselectivity for high yield isomaltooligosaccharides synthesis. Journal of Microbiology and Biotechnology. Dec;19(12):1547-56.

  37. Yonghao Guo, Yanfen Xue, Jun Liu, Quanhui Wang, Yanhe Ma*. 2009. Characterization and function analysis of a Halo-alkaline-adaptable Trk K+ uptake system in Alkalimonas amylolytica strain N10. Science China Life Sciences. Oct;52(10):949-57.

  38. Jiansong Ju, Shujing Xu, Jianxin Wen, Gang Li, Kouhei Ohnishi, Yanfen Xue, Yanhe Ma*. 2009. Characterization of endogenous pyridoxal 5'-phosphate-dependent alanine racemase from Bacillus pseudofirmus OF4. Journal of Bioscience and Bioengineering. Mar;107(3):225-9.

  39. Lang Rao, Xiubo Zhao, Fang Pan, Yin Li, Yanfen Xue, Yanhe Ma*, Jian R. Lu*. 2009. Solution behavior and activity of a halophilic esterase under high salt concentration. PLoS One. Sep 14;4(9):e6980.

  40. Quanhui Wang, Huiming Han, Yanfen Xue, Zhong Qian, Bo Meng, Fuli Peng, Zhuowei Wang, Wei Tong, Chuanqi Zhou, Qian Wang, Yonghao Guo, Gang Li, Siqi Liu*, Yanhe Ma*. 2009. Exploring membrane and cytoplasm proteomic responses of Alkalimonas amylolytica N10 to different external pHs with combination strategy of de novo peptide sequencing. Proteomics. Mar;9(5):1254-73.

  41. Xiaowei Wang, Yanfen Xue, Sanqing Yuan, Cheng Zhou, Yanhe Ma*. 2008. Salinicoccus halodurans sp. nov., a moderate halophile from saline soil in China. International Journal of Systematic and Evolutionary Microbiology. Jul;58(Pt 7):1537-41

  42. Yueling Zhang, Jiansong Ju, Hao Peng, Feng Gao, Cheng Zhou, Yan Zeng, Yanfen Xue, Yin Li, Bernard Henrissat, George F. Gao, Yanhe Ma*. 2008. Biochemical and structural characterization of the intracellular mannanase AaManA of Alicyclobacillus acidocaldarius reveals a novel glycoside hydrolase family belonging to clan GH-A. Journal of Biological Chemistry. Nov 14;283(46):31551-8.

  43. Yueling Zhang, Feng Gao, Yanfen Xue, Yan Zeng, Hao Peng, Jianxun Qi, Yanhe Ma*. 2008. Crystallization and preliminary X-ray study of native and selenomethionyl beta-1,4-mannanase AaManA from Alicyclobacillus acidocaldarius Tc-12-31. Acta Crystallographica Section F Structural Biology and Crystallization Communications. Mar 1;64(Pt 3):209-12

  44. Yanfen Xue, Xinqi Zhang, Cheng Zhou, Yueju Zhao, Don A. Cowan, Shaun Heaphy, William D. Grant, Brian E. Jones, Antonio Ventosa, Yanhe Ma*. 2006. Caldalkalibacillus thermarum gen. nov., sp. nov., a novel alkalithermophilic bacterium from a hot spring in China. International Journal of Systematic and Evolutionary Microbiology. Jun;56(Pt 6):1217-21.

  45. Nan Wang, Yunhua Zhang, Quanhui Wang, Jun Liu, Honglei Wang, Yanfen Xue, Yanhe Ma*. 2006. Gene cloning and characterization of a novel alpha-amylase from alkaliphilic Alkalimonas amylolytica. Biotechnology Journal. Nov;1(11):1258-65.

  46. Jun Liu, Yanfen Xue, Quanhui Wang, Yi Wei, Talia H. Swartz, David B. Hicks, Masahiro Ito, Yanhe Ma*, Terry A. Krulwich. 2005. The activity profile of the NhaD-type Na+(Li+)/H+ antiporter from the soda Lake Haloalkaliphile Alkalimonas amylolytica is adaptive for the extreme environment. Journal of Bacteriology. Nov;187(22):7589-95.

  47. Yanfen Xue, Huapeng Fan, Antonio Ventosa, William D. Grant, Brian E. Jones, Don A. Cowan, Yanhe Ma*. 2005. Halalkalicoccus tibetensis gen. nov., sp. nov., representing a novel genus of haloalkaliphilic archaea. International Journal of Systematic and Evolutionary Microbiology. Nov;55(Pt 6):2501-5.

  申请或授权专利

  1. 马延和,赖志华,周成,薛燕芬;一种木聚糖酶及其编码基因和它们的应用;授权号:ZL201710085783.1

  2. 马延和,葛永德,薛燕芬;一种用于生物合成异戊二烯和异戊烯的酶及其突变;授权号:PCT/CN2016/073413

  3. 马延和,秦宏亮,周成,薛燕芬;一种碱性蛋白酶及其编码基因和它们的应用;授权号:ZL201510194417.0

  4. 马延和,叶金统,周成,薛燕芬;热稳定碱性果胶酶突变体及其编码基因以及它们的应用;授权号:ZL201410067267.2

  5. 马延和,周成,薛燕芬;一种碱性果胶酶及其编码基因和它们的应用;授权号:ZL201410779784.2

  6. 马延和,周成,薛燕芬;一种碱性β-甘露聚糖酶及其编码基因和它们的应用;授权号:ZL201410803360.5

  7. 马延和,周成,薛燕芬;一种嗜碱芽孢杆菌在苎麻生物脱胶中的应用以及苎麻生物脱胶的方法;授权号:ZL201410812506.2

  8. 马延和,朱泰承,孙红兵,李鹏飞,薛燕芬,李寅;一种组成型表达碱性β-甘露聚糖酶的重组菌;授权号:ZL201310120494.2

  9. 马延和,孟莹,薛燕芬,于波;一种生产L-乳酸的方法及其专用芽孢杆菌属菌株;授权号:ZL201210004678.8

  10. 马延和,羡明杰,薛燕芬;羧基转移酶及其编码基因以及它们的应用;申请号:201210534171.3

  11. 马延和,于波,王丽敏,梁音;一种利用菊芋水解液生产D-乳酸的方法;授权号:ZL201210122728.2

  12. 马延和,翟磊,薛燕芬;钠氢泵蛋白及其编码基因和它们的应用;授权号:ZL 201110338064.9

  13. 马延和,柏文琴,薛燕芬;一种耐盐木聚糖酶及其编码基因与应用;授权号:ZL201110317110.7

  14. 马延和,柏文琴,薛燕芬;一种碱性木聚糖酶及其编码基因与应用;授权号:ZL201110317121.5

  15. 马延和,翟磊,薛燕芬;甜菜碱转运蛋白及其编码基因和它们的应用;授权号:ZL201110337978.3

  16. 马延和,翟磊,薛燕芬;胞苷脱氨酶及其编码基因和它们的应用;授权号:ZL201110337927.0

  17. 马延和,翟磊,薛燕芬;跨膜转运蛋白及其编码基因和它们的应用;授权号:ZL201110379016.4

  18. 马延和,翟磊,薛燕芬;钠氢泵蛋白及其编码基因和它们的应用;授权号:ZL201110338562.3

  19. 马延和,翟磊,薛燕芬;一种钾氢泵蛋白及其编码基因和它们的应用;授权号:ZL201110338563.8

  20. 马延和,饶朗,薛燕芬;耐热酯水解酶TClipA3及其编码基因和应用;授权号:ZL 201010282432.8

  21. 马延和,梁朝宁,薛燕芬;一种内切葡聚糖酶的突变体及其编码基因与应用;授权号:ZL 201010505651.8

  22. 马延和,张桂敏,薛燕芬,毛良伟;一种嗜盐纤维素酶及其编码基因与应用;授权号:ZL201010100061.7

  23. 马延和,张桂敏,毛良伟,薛燕芬;一种耐热中性木聚糖酶及其编码基因与应用;授权号:ZL201010152827.6

  24. 马延和,郑迎迎,薛燕芬;一种葡萄糖淀粉酶及其编码基因与应用;授权号:ZL200910091269.4

  25. 马延和,郭永豪,薛燕芬;一种钾离子转运相关蛋白系统及其编码基因簇与应用;授权号:ZL200810119394.7

  26. 马延和,周成,薛燕芬;α-葡萄糖苷酶及其基因和制备方法以及载体和宿主细胞;授权号:ZL200710121922.8

  27. 马延和,张跃灵,薛燕芬;β-甘露聚糖酶及基因和制备方法以及载体和宿主细胞;授权号:ZL200710121923.2

  参编专著

  

  1.《Halophiles and hypersaline environments: current research and future trends》

  Springer,Berlin,2011

  2.《生物炼制-工业过程与产品》(上卷)译著

  化学工业出版社,2007