| 论文题目: | Polyketides with antimicrobial activity from the solid culture of an endolichenic fungus Ulocladium sp. |
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| 作者: | Wang, QX; Bao, L; Yang, XL; Guo, H; Yang, RN; Ren, BA; Zhang, LX; Dai, HQ; Guo, LD; Liu, HW |
| 联系作者: | Zhang, LX |
| 刊物名称: | FITOTERAPIA |
| 期: | 1 |
| 卷: | 83 |
| 页: | 209-214 |
| 年份: | 2012 |
| 影响因子: | 1.848 |
| 论文下载: | 下载地址 |
| 摘要: | Two new polyketides, 7-hydroxy-3, 5-dimethyl-isochromen-1-one (1) and 6-hydroxy-8-methoxy-3a-methyl-3a,9b-dihydro-3H-furo[3,2-c]isochromene-2,5-dione (2), along with eleven known compounds, 5'-methoxy-6-methyl-biphenyl-3,4,3'-triol (3), 7-hydroxy-3-(2-hydroxy-propyl)-5-methyl-isochromen-1-one (4), rubralactone (5), isoaltenuene (6), altenuene (7), dihydroalte-nuenes A(S), altenusin (9), alterlactone (10), 6-O-methylnorlichexanthone (11), norlichexanthone (12), and griseoxanthone C (13) were isolated from the culture of the endolichenic fungus Ulocladium sp. Compound 2 was obtained as a racemate with an unprecedented chemical skeleton. The NMR data assignments for 3 and 4 were achieved for the first time. Compounds 1-13 were screened for their antimicrobial and radical scavenging activities. Compound 1 showed some antifungal activity against Candida albicans SC 5314 with IC50 of 97.93 +/- 1.12 mu M. Compounds 11-13 showed strong activity against Bacillus subtilis with IC50 in the range of 1-5 mu M. Compound 12 significantly inhibited the growth of methicillin-resistant Staphylococcus aureus with IC50 of 20.95 +/- 1.56 mu M. Compounds 9 and 10 showed strong radical scavenging activity in comparison with vitamin C. The plausible biosynthetic pathways for compounds 1, 2, and 4-8 were discussed. (C) 2011 Elsevier B.V. All rights reserved. |
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