| 论文题目: | Isolation, antimicrobial activity, and absolute configuration of the furylidene tetronic acid core of pestalotic acids A-G |
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| 作者: | Zhang, F; Ding, G; Li, L; Cai, XY; Si, YK; Guo, LD; Che, YS |
| 联系作者: | Che, YS |
| 刊物名称: | ORGANIC & BIOMOLECULAR CHEMISTRY |
| 期: | 27 |
| 卷: | 10 |
| 页: | 5307-5314 |
| 年份: | 2012 |
| 影响因子: | 3.696 |
| 论文下载: | 下载地址 |
| 摘要: | Natural products possessing the 3-(furan-2(5H)-ylidene)furan-2,4(3H,5H)-dione (furylidene tetronic acid) skeleton are rare and were encountered only as fungal metabolites. The configurational assignment of the furylidene tetronic acid core using conventional approaches remained a challenge. Pestalotic acids A-G (1-7) are new furylidene tetronic acid derivatives isolated from a plant endophyte Pestalotiopsis yunnanensis. The structure of 1 was elucidated by combination of NMR experiments, X-ray crystallography, and ECD calculations. Compounds 3 and 7 showed significant antimicrobial activity. |
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