| 论文题目: | Determination of Integrated HPV58 Sequences in Cervical Lesions |
|---|---|
| 作者: | Li, H; Zhang, RF; Cai, YP; Li, Y; Cheng, XM; Zhu, BL; Yang, Y; Xiang, Y |
| 联系作者: | Yang, Y |
| 刊物名称: | INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER |
| 期: | 7 |
| 卷: | 22 |
| 页: | 1234-1237 |
| 年份: | 2012 |
| 影响因子: | 1.646 |
| 论文下载: | 下载地址 |
| 摘要: | Integration of high-risk HPV in host genome is an important event in cervical cancer development. This study was aimed to analyze the integration of HPV58, a high-risk type that is prevalent in cervical lesions from southeastern Asia. Detection of integrated papillomavirus sequences by ligation-mediated polymerase chain reaction followed by DNA sequencing revealed 8 integrations in 5 samples, and virus integration was found present in 2 samples with early lesion. Sequence analysis of the viral-cellular junctions showed that E1 disruption in virus genome was an early and common event during HPV58 infection. In 6 integrations, DNA fragments of HPV58 genome integrated into the repetitive element sequences of host genome. |
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