| 论文题目: | Antibacterial Spirobisnaphthalenes from the North American Cup Fungus Urnula craterium |
|---|---|
| 作者: | Liu, XT; Schwan, WR; Volk, TJ; Rott, M; Liu, MM; Huang, P; Liu, Z; Wang, Y; Zitomer, NC; Sleger, C; Hartsel, S; Monte, A; Zhang, LX |
| 联系作者: | Zhang, LX |
| 刊物名称: | JOURNAL OF NATURAL PRODUCTS |
| 期: | 9 |
| 卷: | 75 |
| 页: | 1534-1538 |
| 年份: | 2012 |
| 影响因子: | 3.128 |
| 论文下载: | 下载地址 |
| 摘要: | Urnucratins A-C (1-3), which possess an unusual bisnaphthospiroether skeleton with one oxygen bridge and one C-C bridge and represent a new subclass of bisnaphthalenes, were isolated from the North American cup fungus Urnula craterium. Their structures, including absolute configurations, were determined by means of FIRMS, NMR, and quantum chemical CD calculations. Urnucratin A (1) was found to be active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and Streptococcus pyogenes with MIC values of 2, 1, and 0.5 mu g/mL, respectively. |
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