| 论文题目: | Pleurospiroketals A-E, Perhydrobenzannulated 5,5-Spiroketal Sesquiterpenes from the Edible Mushroom Pleurotus cornucopiae |
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| 作者: | Wang Shao-juan, Bao Li, Han Jun-jie, Wang Quan-xin, Yang Xiao-li, Wen Hua-an, Guo Liang-dong, Li Shao-jie, Zhao Feng, Liu Hong-wei |
| 联系作者: | Liu Hong-wei |
| 刊物名称: | Journal of Natural Products |
| 期: | 1 |
| 卷: | 76 |
| 页: | 45-50 |
| 年份: | 2013 |
| 影响因子: | 3.164 |
| 论文下载: | 下载地址 |
| 摘要: | Five novel perhydrobenzannulated 5,5-spiroketal sesquiterpenes, namely, pleurospiroketals A-E (1-5), were isolated from the culture of the edible mushroom Pleurotus cornucopiae. Pleurospiroketals D (4) and E (5) were obtained as an isomeric mixture with a ratio of 5:4. Their structures were established by NMR, X-ray single-crystal diffraction, and CD data analysis. Pleurospiroketals A-E (1-5) are sesquiterpenoids with a unique benzannulated 5,5-spiroketal skeleton. Compounds 1-3 showed inhibitory activity against nitric oxide production in lipopolysaccharide-activated macrophages with IC50 values of 6.8, 12.6, and 20.8 mu M, respectively. |
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