| 论文题目: | Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012 |
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| 作者: | Liu Ning, Shang Fei, Xi Lijun, Huang Ying |
| 联系作者: | Huang Ying |
| 刊物名称: | Marine Drugs |
| 期: | 5 |
| 卷: | 11 |
| 页: | 1524-33 |
| 年份: | 2013 |
| 影响因子: | 3.704 |
| 论文下载: | 下载地址 |
| 摘要: | Two new oxazole/thiazole derivatives, named tetroazolemycins A (1) and B (2), have been isolated from the acetone extract of the mycelium of Streptomyces olivaceus FXJ8.012 derived from deep-sea water, together with three known compounds, spoxazomicins A-C (3-5), isolated from the fermentation supernatant. The planar structure and relative configuration of tetroazolemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques, and showed to be new pyochelin-type antibiotics. Both compounds showed metal ion-binding activity and their Zn2+ complexes exhibited weak activity against pathogenic bacteria Klebsiella pneumoniae. |
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