| 论文题目: | MicroRNA-146a Feedback Suppresses T Cell Immune Function by Targeting Stat1 in Patients with Chronic Hepatitis B |
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| 作者: | Wang Saifeng, Zhang Xiaojun, Ju Ying, Zhao Bao, Yan Xiaoli, Hu Jun, Shi Lei, Yang Lebing, Ma Zhibo, Chen Lizhao, Liu Yali, Duan Zhongping, Chen Xinyue, Meng Songdong |
| 联系作者: | Songdong Meng |
| 刊物名称: | Journal of immunology |
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| 年份: | 2013 |
| 影响因子: | 5.859 |
| 论文下载: | 下载地址 |
| 摘要: | More than 350 million people are chronically infected with hepatitis B virus, and dysfunctional T cell responses contribute to persistent viral infection and immunopathogenesis in chronic hepatitis B (CHB). However, the underlying mechanisms of T cell hypo-responsiveness remain largely undefined. Given the important role of microRNA-146a (miR-146a) in diverse aspects of lymphocyte function, we investigated the potential role and mechanism of miR-146a in regulating T cell immune responses in CHB. We found that miR-146a expression in T cells is significantly up-regulated in CHB compared with healthy controls, and miR-146a levels were correlated with serum alanine amino transaminase levels. Both inflammatory cytokines and viral factors led to miR-146a up-regulation in T cells. Stat1 was identified as a miR-146a target that is involved in antiviral cytokine production and the cytotoxicity of CD4+and CD8+T cells. In vitro blockage of miR-146a in T cells in CHB greatly enhanced virus-specific T cell activity. Therefore, our work demonstrates that miR-146a up-regulation in CHB causes impaired T cell function, which may contribute to immune defects and immunopathogenesis during chronic viral infection. |
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