| 论文题目: | Dioxatricyclic and oxabicyclic polyketides from Trichocladium opacum |
|---|---|
| 作者: | Chen Shenxi, Ren Fengxia, Niu Shubin, Liu Xingzhong, Che Yongsheng* |
| 联系作者: | Che Yongsheng* |
| 刊物名称: | J Nat Prod |
| 期: | 77 |
| 卷: | 1 |
| 页: | 9-14 |
| 年份: | 2014 |
| 影响因子: | 3.267 |
| 论文下载: | 下载地址 |
| 摘要: | Five new polyketides, trichocladinols D-H (1-5) with dioxatricyclic (1-3) and oxabicyclic (4 and 5) skeletons, and the known massarilactone C (6) were isolated from the solid-substrate fermentation cultures of the ascomycete fungus Trichocladium opacum. The structures of 1-5 were determined mainly by NMR experiments, and 1, 3, and 4 were confirmed by X-ray crystallography. The absolute configurations of 1 and 3 were assigned by X-ray crystallography using Cu Kalpha radiation, whereas that of C-5 in 2 and 4 was deduced via the circular dichroism (CD) data. Compounds 2-4 showed weak cytotoxicity against the human tumor cell lines A549, HCT116, and SW480. |
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