| 论文题目: | Guanacastane Diterpenoids from the Plant Endophytic Fungus Cercospora sp |
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| 作者: | Feng Yu, Ren Fengxia, Niu Shubin, Wang Lin, Li Li, Liu Xingzhong, Che Yongsheng* |
| 联系作者: | Che Yongsheng* |
| 刊物名称: | J Nat Prod |
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| 年份: | 2014 |
| 影响因子: | 3.267 |
| 论文下载: | 下载地址 |
| 摘要: | Cercosporenes A-F (1-6, respectively), six new guanacastane diterpenes, including a homodimer (5) and a heterodimer (6), were isolated from the crude extract of the fungus Cercospora sp., endophytic to the medicinal plant Fallopia japonica. The structures of 1-6 were elucidated by nuclear magnetic resonance experiments, and 4 and 5 were further confirmed by X-ray crystallography. The absolute configuration of 1 and 3 was assigned by electronic circular dichroism calculations, whereas that of 6 was deduced by the application of the circular dichroism exciton chirality method. In addition to its cytotoxicity against a panel of five human tumor cell lines, HeLa, A549, MCF-7, HCT116, and T24, heterodimer 6 also induced autophagy in HCT116 cells. |
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