| 论文题目: | High expression of long non-coding RNA H19 is required for efficient tumorigenesis induced by Bcr-Abl oncogene |
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| 作者: | Guo Guijie, Kang Qingzheng, Chen Qinghuang, Chen Zhilong, Wang Jun, Tan Li, Chen Ji-Long* |
| 联系作者: | Chen Ji-Long* |
| 刊物名称: | FEBS Lett |
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| 年份: | 2014 |
| 影响因子: | 3.478 |
| 论文下载: | 下载地址 |
| 摘要: | Dysregulation of non-coding RNA H19 has been observed in various tumors. However, it remains unknown whether H19 is involved in Bcr-Abl-induced leukemia. Here, we demonstrate a critical requirement for H19 in Bcr-Abl-mediated tumorigenesis. H19 was highly expressed in Bcr-Abl-transformed cell lines and primary cells derived from patients in a Bcr-Abl kinase-dependent manner. Silencing H19 expression sensitized leukemic cells to undergo imatinib-induced apoptosis and inhibited Bcr-Abl-induced tumor growth. Furthermore, H19 was shown to be regulated by c-Myc in Bcr-Abl-expressing cells. These results reveal an important role H19 plays in Bcr-Abl-mediated transformation and provide novel insights into complex mechanisms underlying Bcr-Abl-induced cancers. |
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