| 论文题目: | Heat shock protein gp96 adjuvant induces T cell responses and cross-protection to a split influenza vaccine |
|---|---|
| 作者: | Ju Ying#, Fan Hongxia#, Liu Jun, Hu Jun, Li Xinghui, Li Changfei, Chen Lizhao, Gao Qiang, George F Gao, Meng Songdong* |
| 联系作者: | Meng Songdong* |
| 刊物名称: | Vaccine |
| 期: | |
| 卷: | |
| 页: | |
| 年份: | 2014 |
| 影响因子: | 3.458 |
| 论文下载: | 下载地址 |
| 摘要: | The commonly used inactivated or split influenza vaccines induce only induce minimal T cell responses and are less effective in preventing heterologous virus infection. Thus, developing cross-protective influenza vaccines against the spread of a new influenza virus is an important strategy against pandemic emergence. Here we demonstrated that immunization with heat shock protein gp96 as adjuvant led to a dramatic increased antigen-specific T cell response to a pandemic H1N1 split vaccine. Notably, gp96 elicited a cross-protective CD8+ T cell response to the internal conserved viral protein NP. Although the split pH1N1vaccine alone has low cross-protective efficiency, adding gp96 as an adjuvant effectively improved the cross-protection against challenge with a heterologous virus in mice. Our study reveals the novel property of gp96 in boosting the T cell response against conserved epitopes of influenza virus and its potential use as an adjuvant for human pre-pandemic inactivated influenza vaccines against different viral subtypes. |
京公网安备 11010502044263号