| 论文题目: | Three new sterigmatocystin analogues from marine-derived fungus Aspergillus versicolor MF359 |
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| 作者: | Song Fuhang, Ren Biao, Chen Caixia, Yu Ke, Liu Xinru, Zhang Yuhan, Yang Na, He Hongtao, Liu Xueting, Dai Huanqin, Zhang Lixin* |
| 联系作者: | Zhang Lixin* |
| 刊物名称: | Appl Microbiol Biotechnol |
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| 年份: | 2014 |
| 影响因子: | 3.762 |
| 论文下载: | 下载地址 |
| 摘要: | During the systematic screening of active compounds from marine-derived fungi, the extract of a strain of Aspergillus versicolor MF359 isolated from a marine sponge of Hymeniacidon perleve was identified for detailed chemical investigation. Three new secondary metabolites, named hemiacetal sterigmatocystin (1), acyl-hemiacetal sterigmatocystin (2), and 5-methoxydihydrosterigmatocystin (3), together with a known compound, aversin (4), were characterized. 1 represents a first structure of sterigmatocystin hemiacetal from nature. The antibacterial activities of these identified compounds were evaluated against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa. Compound 3 showed activity against S. aureus and B. subtilis with MIC values of 12.5 and 3.125 mug/mL, respectively. |
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