| 论文题目: | Cytotoxic Cleistanthane and Cassane Diterpenoids from the Entomogenous Fungus Paraconiothyrium hawaiiense |
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| 作者: | Chen Shenxi, Zhang Yang, Niu Shubin, Liu Xingzhong, Che Yongsheng* |
| 联系作者: | Che Yongsheng* |
| 刊物名称: | J Nat Prod |
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| 年份: | 2014 |
| 影响因子: | 3.267 |
| 论文下载: | 下载地址 |
| 摘要: | Hawaiinolides A-D (1-4), four new secondary metabolites including three cleistanthane (1, 3, and 4) and one cassane (2) type of diterpene lactones, were isolated from the crude extract of Paraconiothyrium hawaiiense, a fungus entomogenous to the Septobasidium-infected insect Diaspidiotus sp. The structures of 1-4 were elucidated by nuclear magnetic resonance experiments, and 1 and 3 were further confirmed by X-ray crystallography. The absolute configuration of 1 was assigned via single-crystal X-ray diffraction analysis using Cu Kalpha radiation, whereas that of 2-4 was deduced via the circular dichroism data. Compound 1 showed significant cytotoxicity against a small panel of five human tumor cell lines, A549, T24, HeLa, HCT116, and MCF-7. |
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