| 论文题目: | Sterhirsutins A and B, Two New Heterodimeric Sesquiterpenes with a New Skeleton from the Culture of Stereum hirsutum Collected in Tibet Plateau |
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| 作者: | Qi Qiu-Yue, Bao Li, Ren Jin-Wei, Han Jun-Jie, Zhang Zong-Yao, Li Yi, Yao Yi-Jian, Cao Rui, Liu Hong-Wei* |
| 联系作者: | Liu Hong-Wei* |
| 刊物名称: | Org Lett |
| 期: | 16 |
| 卷: | 19 |
| 页: | 5092-5 |
| 年份: | 2014 |
| 影响因子: | 5.72 |
| 论文下载: | 下载地址 |
| 摘要: | Two new heterodimeric sesquiterpenes, sterhirsutins A (1) and B (2), and two new sesquiterpenes, hirsutic acids D-E (3 and 4), were identified from the culture of Stereum hirsutum. The absolute configurations in 1 and 2 were confirmed by single-crystal X-ray diffraction experiments and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 are likely biosynthesized from a hirsutane-type sesquiterpene and alpha-humulene by a hetero-Diels-Alder cycloaddition. Compounds 1-4 showed cytotoxicity against K562 and HCT116 cell lines. |
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