| 论文题目: | NRAV, a Long Noncoding RNA, Modulates Antiviral Responses through Suppression of Interferon-Stimulated Gene Transcription. |
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| 作者: | Ouyang Jing, Zhu Xiaomei, Chen Yuhai, Wei Haitao, Chen Qinghuang, Chi Xiaojuan, Qi Baomin, Zhang Lianfeng, Zhao Yi, George Fu Gao, Wang Guoshun, Chen Ji-Long* |
| 联系作者: | Chen Ji-Long* |
| 刊物名称: | Cell Host Microbe |
| 期: | 5 |
| 卷: | 16 |
| 页: | 616-626 |
| 年份: | 2014 |
| 影响因子: | 13.573 |
| 论文下载: | 下载地址 |
| 摘要: | Long noncoding RNAs (lncRNAs) modulate various biological processes, but their role in host antiviral responses is largely unknown. Here we identify a lncRNA as a key regulator of antiviral innate immunity. Following from the observation that a lncRNA that we call negative regulator of antiviral response (NRAV) was dramatically downregulated during infection with several viruses, we ectopically expressed NRAV in human cells or transgenic mice and found that it significantly promotes influenza A virus (IAV) replication and virulence. Conversely, silencing NRAV suppressed IAV replication and virus production, suggesting that reduction of NRAV is part of the host antiviral innate immune response to virus infection. NRAV negatively regulates the initial transcription of multiple critical interferon-stimulated genes (ISGs), including IFITM3 and MxA, by affecting histone modification of these genes. Our results provide evidence for a lncRNA in modulating the antiviral interferon response. |
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