| 论文题目: | Identification of Oxaphenalenone Ketals from the Ascomycete Fungus Neonectria sp |
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| 作者: | Ren Jinwei, Niu Shubing, Li Li, Geng Zhufeng, Liu Xingzhong, and Che Yongsheng*. |
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| 刊物名称: | J Nat Prod |
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| 年份: | 2015 |
| 影响因子: | 3.395 |
| 论文下载: | 下载地址 |
| 摘要: | Neonectrolides B-E (4-7), four new oxaphenalenone ketals incorporating the new furo[2,3-b]isochromeno[3,4,5-def]chromen-11(6aH)-one skeleton, were isolated from the fermentation extract of the ascomycete fungus Neonectria sp. in an in-depth investigation guided by HPLC fingerprint and a cytotoxicity assay. The previously identified oxaphenalenone spiroketal neonectrolide A (1) and its putative biosynthetic precursors (2 and 3) were also reisolated in the current work. The structures of 4-7 were primarily elucidated by interpretation of NMR spectroscopic data, and the absolute configurations were deduced by electronic circular dichroism calculations. Compound 6 showed cytotoxic effects against four of the six human tumor cell lines tested. Biosynthetically, compounds 4-7 could be derived via the Diels-Alder reaction cascades starting from derivatives of the co-isolated metabolites 2 and 3. |
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