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论文题目: Gloeophyllins A-J, Cytotoxic Ergosteroids with Various Skeletons from a Chinese Tibet Fungus Gloeophyllum abietinum
作者: Han Jun-Jie, Bao Li, Tao Qiao-Qiao, Yao Yi-Jian, Liu Xing-Zhong, Yin Wen-Bing, and Liu Hong-Wei*.
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刊物名称: Org Lett
期: 17
卷: 10
页: 2538-41
年份: 2015
影响因子: 5.849
论文下载: 下载地址
摘要: Ten new ergosteroids, gloeophyllins A-J (1-10), have been isolated from the solid cultures of Gloeophyllum abietinum. The absolute configurations of 1, 2, and 9 were determined by X-ray crystallographic analysis. Compound 1 has a rare C-nor-D-homosteroid skeleton. Compound 9 possesses an unusual ergostane skeleton having a 10-oxabicyclo [4.3.1] decane moiety replacing 6/5 fused C/D rings. Compound 10 represents the first ergosteroid featuring the cleavage of a C8-C14 bond. The cytotoxicity of 1-10 was tested against the human cancer cell lines K562 and HCT116. The biosynthetic pathway for 1-10 is postulated.