| 论文题目: | Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice |
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| 作者: | Bi Yuhai* , Xiao Haixia , Chen Quanjiao , Wu Yan , Fu Lifeng , Quan Chuansong , Wong Gary , Liu Jun , Haywood Joel , Liu Yingxia , Zhou Boping , Yan Jinghua , Liu Wenjun , and Gao George F.*. |
| 联系作者: | |
| 刊物名称: | Journal of Virology |
| 期: | 4 |
| 卷: | 90 |
| 页: | 2142-2149 |
| 年份: | 2016 |
| 影响因子: | 4.609 |
| 论文下载: | 下载地址 |
| 摘要: | The neuraminidase stalk of the newly emerged H7N9 influenza virus possesses a 5-amino-acid deletion. This study focuses on characterizing the biological functions of H7N9 with varied neuraminidase stalk lengths. Results indicate that the 5-amino-acid deletion had no impact on virus infectivity or replication in vitro or in vivo compared to that of a virus with a full-length stalk, but enhanced virulence in mice was observed for H7N9 encoding a 19-to 20-amino-acid deletion, suggesting that N9 stalk length impacts virulence in mammals, as N1 stalk length does. |
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