| 论文题目: | The gray phenotype and tristable phenotypic transitions in the human fungal pathogen Candida tropicalis |
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| 作者: | Zhang Yulong, Tao Li, Zhang Qiuyu, Guan Guobo, Nobile Clarissa J, Zheng Qiushi, Ding Xuefen, and Huang Guanghua* |
| 联系作者: | |
| 刊物名称: | Fungal Genet Biol |
| 期: | |
| 卷: | 93 |
| 页: | 10-16 |
| 年份: | 2016 |
| 影响因子: | 3.227 |
| 论文下载: | 下载地址 |
| 摘要: | Phenotypic plasticity, the ability to switch between different morphological types, plays critical roles in environmental adaptation, leading to infections, and allowing for sexual reproduction in pathogenic Candida species. Candida tropicalis, which is both an emerging human fungal pathogen and an environmental fungus, can switch between two heritable cell types termed white and opaque. In this study, we report the discovery of a novel phenotype in C. tropicalis, named the gray phenotype. Similar to Candida albicans and Candida dubliniensis, white, gray, and opaque cell types of C. tropicalis also form a tristable switching system, where gray cells are relatively small and elongated. In C. tropicalis, gray cells exhibit intermediate levels of mating competency and virulence in a mouse systemic infection model compared to the white and opaque cell types, express a set of cell type-enriched genes, and exhibit both common and species-specific biological features. The key regulators of white-opaque transitions, Wor1 and Efg1, are not required for the gray phenotype. A comparative study of the gray phenotypes in C. tropicalis, C. albicans, and C. dubliniensis provides clues to explain the virulence properties and niche preferences of C. tropicalis. |
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