| 论文题目: | Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans |
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| 作者: | Liu, Liwei Hao, Tingting Xie, Zhoujie Horsman, Geoff P Chen, Yihua |
| 联系作者: | Chen, Yihua* |
| 刊物名称: | Sci Rep |
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| 年份: | 2016 |
| 影响因子: | 5.525 |
| 论文下载: | 下载地址 |
| 摘要: | Streptococcus mutans is a major pathogen causing human dental caries. As a Gram-positive bacterium with a small genome (about 2 Mb) it is considered a poor source of natural products. Due to a recent explosion in genomic data available for S. mutans strains, we were motivated to explore the natural product production potential of this organism. Bioinformatic characterization of 169 publically available genomes of S. mutans from human dental caries revealed a surprisingly rich source of natural product biosynthetic gene clusters. Anti-SMASH analysis identified one nonribosomal peptide synthetase (NRPS) gene cluster, seven polyketide synthase (PKS) gene clusters and 136 hybrid PKS/NRPS gene clusters. In addition, 211 ribosomally synthesized and post-translationally modified peptides (RiPPs) clusters and 615 bacteriocin precursors were identified by a combined analysis using BAGEL and anti-SMASH. S. mutans harbors a rich and diverse natural product genetic capacity, which underscores the importance of probing the human microbiome and revisiting species that have traditionally been overlooked as "poor" sources of natural products. |
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