| 论文题目: | Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies |
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| 作者: | Tan, Shuguang Chen, Danqing Liu, Kefang He, Mengnan Song, Hao Shi, Yi Liu, Jun Zhang, Catherine W-H Qi, Jianxun Yan, Jinghua Gao, Shan Gao, George F |
| 联系作者: | Gao, Shan* Gao, George F* |
| 刊物名称: | Protein Cell |
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| 年份: | 2016 |
| 影响因子: | 3.043 |
| 论文下载: | 下载地址 |
| 摘要: | Antibody-based PD-1/PD-L1 blockade therapies have taken center stage in immunotherapies for cancer, with multiple clinical successes. PD-1 signaling plays pivotal roles in tumor-driven T-cell dysfunction. In contrast to prior approaches to generate or boost tumor-specific T-cell responses, antibody-based PD-1/PD-L1 blockade targets tumor-induced T-cell defects and restores pre-existing T-cell function to modulate antitumor immunity. In this review, the fundamental knowledge on the expression regulations and inhibitory functions of PD-1 and the present understanding of antibody-based PD-1/PD-L1 blockade therapies are briefly summarized. We then focus on the recent breakthrough work concerning the structural basis of the PD-1/PD-Ls interaction and how therapeutic antibodies, pembrolizumab targeting PD-1 and avelumab targeting PD-L1, compete with the binding of PD-1/PD-L1 to interrupt the PD-1/PD-L1 interaction. We believe that this structural information will benefit the design and improvement of therapeutic antibodies targeting PD-1 signaling. |
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