| 论文题目: | Chlorotheolides A and B, Spiroketals Generated via Diets-Alder Reactions in the Endophytic Fungus Pestalotiopsis theae |
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| 作者: | Liu Ling , Han Yu , Xiao Junhai , Li Li , Guo Liangdong , Jiang Xuejun , Kong Lingyi* , and Che Yongsheng*. |
| 联系作者: | |
| 刊物名称: | Journal of Natural Products |
| 期: | 79 |
| 卷: | |
| 页: | 2616-2623 |
| 年份: | 2016 |
| 影响因子: | 3.644 |
| 论文下载: | 下载地址 |
| 摘要: | Chlorotheolides A (1) and B (2), two new spiroketals possessing the unique [4,7]methanochromene and dispirotrione skeletons, respectively, and their putative biosynthetic precursors, 1-undecen-2,3-dicarboxylic acid (3) and maldoxin (4), were isolated from the solid substrate fermentation of the plant endophytic fungus Pestalotiopsis theae (N635). Their structures were elucidated based on NMR spectroscopic data and electronic circular dichroism calculations. Biogenetically, compounds 1 and 2 could be generated from the co-isolated 3 and 4 via Diels Alder reactions. Chlorotheolide (2) showed an antiproliferative effect against the human tumor cell line HeLa and induced an autophagic process in the cells. |
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