| 论文题目: | Deletion of a Histone Acetyltransferase Leads to the Pleiotropic Activation of Natural Products in Metarhizium robertsii |
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| 作者: | Fan Aili, Mi Wubin, Liu Zhiguo, Zeng Guohong, Zhang Peng, Hu Youcai, Fang Weiguo, and Yin Wen-Bing*. |
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| 刊物名称: | Org Lett |
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| 年份: | 2017 |
| 影响因子: | 6.033 |
| 论文下载: | 下载地址 |
| 摘要: | Histone deacetylation normally decreases the gene expression in organisms. By genome-wide deletions of epigenetic regulators in entomopathogenic fungus Metarhizium robertsii, unexpected activations of orphan secondary metabolite genes have been found upon the disruption of a histone acetyltransferase (HAT) gene Hat1. This led to the characterization of 11 new natural products, including eight isocoumarin derivatives meromusides A-H and two nonribosomal peptides meromutides A and B. Therefore, disruption of HAT represents a new approach to mine chemical diversity from fungi. |
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