| 论文题目: | Secretory proteins are delivered to the septin-organized penetration interface during root infection by Verticillium dahliae |
|---|---|
| 作者: | Zhou Ting-Ting, Zhao Yun-Long, and Guo Hui-Shan*. |
| 联系作者: | |
| 刊物名称: | PLOS Pathogens |
| 期: | 13 |
| 卷: | 3 |
| 页: | e1006275 |
| 年份: | 2017 |
| 影响因子: | 7.758 |
| 论文下载: | 下载地址 |
| 摘要: | Author summary Pathogens secrete effector proteins as molecular weapons to evade or suppress plant immunity. However, the mechanism(s) by which root-infecting fungal pathogens secrete secretory effector proteins remains unexplored. We previously reported that Verticillium dahliae, a root-infecting phytopathogenic fungus, forms a specialized infection structure known as a hyphopodium that develops a penetration peg to pierce plant roots. In this study, we observed that after penetration, the penetration peg-developed hyphal neck, partitioning the hyphopodium and invasive hypha, came into close contact with the host, forming the fungus-host penetration interface. NADPH oxidase B (VdNoxB) regulated the cytoskeletal organization of the septin ring at the hyphal neck. Importantly, the penetration interface was a preferential site for secretion of signal peptide-containing proteins. Septin plays an important role in the efficient delivery of secretory proteins to the penetration interface. Moreover, the conventional fungal ER-to-Golgi secretion pathway, endosome-mediated transport and the exocyst complex are involved in the delivery of secretory proteins to the penetration interface. Together, our data demonstrate that the V. dahliae infection structure functions as a key signaling hub during plant infection and is the apparatus that not only breaches host cells but also provides a unique interface for the secretion of fungal effectors. |
京公网安备 11010502044263号